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Retinal Vessel Analyzer
 
The system for ophthalmic and interdisciplinary vascular research.
  • Clinical studies in the field of vascular research
  • Vessel analysis for e.g. glaucoma, AMD, diabetic retinopathy
  • Vessel analysis for systemic vascular risks (e.g. stroke, diabetes, hearth attack)
  • Endothelial research
  • Drug research (e.g. efficacy monitoring / individualized therapy)
  • Development of new methods for screening and early detection of vascular diseases
 
Basic Functions
 
  • Online measurement of vessel diameter along vessel segments over time.
  • Analysis of measured values: Functional analysis, Vasomotorics, local analysis, time analysis.
  • Dynamic Vessel Analysis with provocation by drugs, different breathing gases, intraocular changes etc.
  • Dynamic Vessel Analysis with Flicker Light Induced Provocation (FLIP)
  • Storage and offline analysis of captured video sequences; multiple graphical presentation options.
  • Interfaces to ECG, blood pressure monitoring and others.
imedos RVA Research Retinal Vessel Analyzer has been developed for the needs of research institutions and practices who do basic research or participate in clinical trials. As a system with unique performance parameters it allows simple adaptation to almost any kind of clinical hypothesis in the area of vascular research. Its special software is designed to allow connections to other data sources as well as easy changes to generate different graphical data representation.

Vessel analysis was developed by imedos in cooperation with universities and is based on proprietary technologies. Over the last 5 years these technologies have been applied in our RVA Research Retinal Vessel Analyzer and have been used in many clinical trials around the world.

Dynamic Vessel Analysis is the key technology for the early detection of functional vessel changes.

Thus Dynamic Vessel Analysis is the perfect basis for the examination of various systemic changes and physiological and patho-physiological states of retinal microcirculation. And has a tremendous potential for further applications in the future.

With the flicker RVA module also clinical routine vessel analysis can be performed with the RVA.
     
How Does It Work    
     
  The patient is positioned in front of the mydriatic fundus camera and the diameter of selected vessel segments will be measured automatically. During the measurement flicker light provocation of the retina is performed. The flicker light induced diameter changes are recorded over time for all locations along the segments.

An easy to read graph is generated (FLIP Graph) which describes the capability od the vessel to dilate.

This function is highly standardized and thus applicable in clinical routine. Latest clinical results show reduced flicker response in patients with untreated hypertension thus demonstrating correlations between the retinal vessels and vessels in other parts of the body.

With this approach DVA became a clinically applicable method for the early detection of changes in auto regulative vessel behaviour.
 
The patient is measured with a mydriatic fundus camera. Changes to the functional behaviour of the vessels and vessel diameters can be induced by different means e.g. flicker light, drugs, oxygen or laser treatment. Segment by segment these changes are continuously recorded and evaluated over time. A variety of graphical representations can be generated.

If the flicker function is used, an easy to read graph can be generated (FLIP-Graph), which describes the capability of the vessels to autoregulate. And this function is highly standardized and thus applicable in clinical routine. Latest clinical results show reduced flicker response in patients with untreated arterial hypertension, thus demonstrating correlations between the retinal vessels and vessels in other parts of the body.

The RVA has its own software packages that are optimized for research use of the system. They allow for easy links to other data input sources and exports of data in formats required by researchers.
 
Additional Features
 
  • Database for patient related measurement data
  • PC controlled recording and archiving of video sequences to enable future offline evaluations
  • Documentation of protocols including location dependent graph, averages and standard deviation
  • On-line graphics of the behaviour of vessels
  • Diagram of diameter along the vessel
  • 3D graphics (time, location and diameter)
  • Documentation of location of measurement
  • Network capability
  • Several export and import formats
  • Pulse analysis - signal averaging
  • Automatic vessel tracking and error reporting
 
Tehcnical Components
 
  • Modified mydriatic fundus camera
  • Flicker RVA module
  • Measuring CCD camera with framegrabber
  • Video recorder
  • PC based RVA-hardware
 
     
     
     
 
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